OGA inhibition by GlcNAc-selenazoline.
نویسندگان
چکیده
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable ability to induce hyper-O-GlcNAc-ylation, and the two show similar reduction of insulin-stimulated translocation of glucose transporter 4 in differentiated 3T3 adipocytes.
منابع مشابه
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry
دوره 18 19 شماره
صفحات -
تاریخ انتشار 2010